Puxico is a small town in Stoddard County, Missouri, US, with a population of just over 800 as of the 2020 census. Established in 1872, the town was named after the Puxico Creek, which runs through it. Puxico is known for its well-preserved historic downtown district, which includes the Puxico Square, listed on the National Register of Historic Places. The town also hosts the annual Puxico Homecoming, a popular event that attracts thousands of visitors each year.
Dollar General takes the top spot among Dollar Stores and Deep Discount Stores in Puxico, Missouri with 1 locations as of April 12, 2024.